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A postdoctoral position is open in the Viral Tumorigenesis group, Genome-Scale Biology Program, Biomedicum Helsinki, University of Helsinki, Finland.
We are looking for an enthusiastic, highly motivated, and hard-working candidate with a proven track record of successful scientific work for a project on viral tumorigenesis using Kaposi’s sarcoma herpesvirus (KSHV) as a model. Kaposi’s sarcoma (KS) is an angiogenic tumor of endothelial origin, and we are using endothelial cells as well as patient-derived KSHV-lymphoma cells as model systems in the studies. We are using functional genomics, sophisticated cell biological, and in vivo approaches to identify novel viral and cellular effectors in the signaling cascades leading to cell transformation. The project focuses on novel mechanisms of cellular reprogramming and oncogenesis using KSHV-infected lymphatic endothelial cells as a biologically relevant model for KS development.
The research group is a member in the National Centre of Excellence for Translational Genome-Scale Biology, and has focused on understanding mechanisms of cell transformation and pathogenesis of a human oncogenic virus. This has lead to significant contributions in the field such as demonstration of manipulation of apoptotic pathways by a viral oncogene (Ojala et al., Nat Cell Biol 2000), identification of p53 reactivation as a novel therapeutic modality for KSHV associated lymphomas (Sarek et al. J. Clin, Invest. 2007; Sarek & Ojala, Cell Cycle 2007), and novel signaling pathways and cellular proteins involved in viral reactivation and tumorigenesis (Varjosalo et al., Cell 2008 & Cheng et al., PLoS Pathogens 2009). Suitable candidates for the postdoctoral position should have an interest in cancer biology and preferably experience in the following areas: molecular and cell biology, cell signaling, endothelial cell biology, general cell biology, and mouse models.
Fecha cierre: 29/10/2010
* To apply, e-mail your application, CV, and contact information of three references to:
Email: firstname.lastname@example.org .
* Additional information about the research group and institute Web: http://research.med.helsinki.fi/gsb/ojala/default.htm
Lugar: FINLANDIA - Finlandia